Optimized Nano Hydrogels for Tropical Wound Care: Integrating Chromolaena odorata and Carbopol 980 for Enhanced Healing

Abstract

This study focuses on the formulation and evaluation of nano hydrogels containing Chromolaena odorata leaf extract, using Carbopol 980 as a gelling agent. Chromolaena odorata, known for its antimicrobial and anti-inflammatory properties, is traditionally used in Southeast Asia for wound healing. The primary objective was to determine the optimal concentration of Carbopol 980 for nano hydrogel formulations with desirable physical and chemical properties suitable for wound care, particularly in tropical climates like Thailand. The hydrogels were prepared with varying concentrations of Carbopol 980 (0.5%, 1.0%, 1.5%, and 2.0%). Evaluations were conducted on particle size, pH, viscosity, spreadability, and adhesion. The results demonstrated that the 0.5% concentration of Carbopol 980 yielded the most favorable properties, with a particle size of approximately 412.9 nm, optimal viscosity, and high spreadability, making it suitable for wound dressing applications. Nano hydrogels offer several advantages, such as controlled release of active substances and improved drug delivery, which are crucial for wound healing in tropical regions. The study highlights the potential of Chromolaena odorata as an affordable and effective ingredient in wound care products, leveraging local resources and traditional medicinal knowledge in Thailand. The findings suggest that these nano hydrogel formulations could enhance wound healing, and future research should focus on clinical trials to further assess their effectiveness in real-world applications.