Policies, Progress and Challenges in Addressing Antimicrobial Resistance
Abstract
Antimicrobial Resistance (AMR) poses a critical challenge to global healthcare systems, including Norway, despite its relatively low antibiotic consumption rate. This study aims to evaluate antibiotic resistance rates, analyze government policies, and explore progress in the development of antibiotics and alternative therapies in Norway. A qualitative descriptive design with a case study approach was used, combining data from policy documents, research articles, and semi-structured interviews with 30 respondents, including microbiologists, healthcare professionals, and policymakers from Oslo, Bergen, and Tromsø. Findings reveal that although Norway’s antibiotic resistance rate is lower than other European countries, certain bacteria, such as MRSA, Enterococcus faecium, and ESBL-producing E. coli, remain problematic in hospitals. The Norwegian government’s strict management policies, including prescription restrictions and diagnostic mandates, have effectively reduced resistance. In addition, research on new antibiotics and alternative therapies, such as phage therapy and probiotics, shows promise but requires further exploration. Challenges such as high R&D costs, resource constraints, and the global spread of resistant bacteria hinder progress. This study highlights the need for international collaboration, innovative funding models, and expanded research into alternative therapies. Future studies should address hospital-specific resistance challenges and strategies to accelerate antibiotic development. Norway’s experience provides valuable insights for global AMR management and policy.
Downloads


References
G. Muteeb, M. T. Rehman, M. Shahwan, and M. Aatif, “Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review,” Pharmaceuticals (Basel), vol. 16, no. 11, 2023.
G. Gutema, H. Håkonsen, E. Engidawork, and E.-L. Toverud, “Antibiotic stewardship in Norway: Are strategies for rational use of antibiotics followed in Norwegian healthcare system?” medRxiv, doi: 10.1101/2021.02.01.21250947.
T. Pulingam, T. Parumasivam, A. M. Gazzali, A. M. Sulaiman, J. Y. Chee, M. Lakshmanan, C. F. Chin, and K. Sudesh, “Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome,” European Journal of Pharmaceutical Sciences, vol. 170, 2022.
X. Sánchez, M. Orrico, T. Morillo, A. Manzano, R. Jimbo, and L. Armijos, “Reducing unnecessary antibiotic prescription through implementation of a clinical guideline on self-limiting respiratory tract infections,” PLOS ONE, Apr. 1, 2021.
M. A. Salam, M. Y. Al-Amin, M. T. Salam, J. S. Pawar, N. Akhter, A. A. Rabaan, and M. A. A. Alqumber, “Antimicrobial resistance: A growing serious threat for global public health,” Healthcare (Basel), vol. 11, no. 13, 2023.
T. M. Uddin, A. J. Chakraborty, A. Khusro, B. M. R. M. Zidan, S. Mitra, T. B. Emran, K. Dhama, M. K. H. Ripon, M. Gajdács, M. U. K. Sahibzada, M. J. Hossain, and N. Koirala, “Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects,” Journal of Infection and Public Health, vol. 14, no. 12, pp. 1750–1766, 2021.
M. Aijaz, M. Ahmad, M. A. Ansari, and S. Ahmad, “Antimicrobial resistance in a globalized world: Current challenges and future perspectives,” International Journal of Pharmaceutics and Drug Design, vol. 1, pp. 7–22, 2023.
J. Patel, A. Harant, G. Fernandes, A. J. Mwamelo, W. Hein, and D. Dekker, “Measuring the global response to antimicrobial resistance, 2020–21: A systematic governance analysis of 114 countries,” The Lancet Infectious Diseases, vol. 23, no. 6, pp. 706–718, 2023.
N. B. Jadeja and A. Worrich, “From gut to mud: Dissemination of antimicrobial resistance between animal and agricultural niches,” Environmental Microbiology, vol. 28, pp. 3290–3306, 2022.
C. Uruén, G. Chopo-Escuin, J. Tommassen, R. C. Mainar-Jaime, and J. Arenas, “Biofilms as promoters of bacterial antibiotic resistance and tolerance,” Antibiotics (Basel), vol. 10, no. 1, 2020.
S. Bhattacharyya, M. Bhattacharyya, D. M. Pfannenstiel, A. K. Nandi, Y. Hwang, K. Ho, and R. M. Harshey, “Efflux-linked accelerated evolution of antibiotic resistance at a population edge,” Molecular Cell, vol. 82, no. 22, pp. 4368 - 4385, 2022.
H. Giamarellou, L. Galani, T. Karavasilis, K. Ioannidis, and I. Karaiskos, “Antimicrobial stewardship in the hospital setting: A narrative review,” Antibiotics (Basel), vol. 12, no. 10, 2023.
J. Bengtsson-Palme, A. Abramova, T. U. Berendonk, L. P. Coelho, S. K. Forslund, R. Gschwind, A. Heikinheimo, V. H. Jarquín-Díaz, A. A. Khan, U. Klümper, U. Löber, M. Nekoro, A. D. Osińska, S. Ugarcina Perovic, T. Pitkänen, E. K. Rødland, E. Ruppé, Y. Wasteson, A. L. Wester, and R. Zahra, “Towards monitoring of antimicrobial resistance in the environment: For what reasons, how to implement it, and what are the data needs?” Environment International, vol. 178, 2023.
D. Yamin, V. Uskoković, A. M. Wakil, M. D. Goni, S. H. Shamsuddin, F. H. Mustafa, W. A. Alfouzan, M. Alissa, A. Alshengeti, R. H. Almaghrabi, M. A. A. Fares, M. Garout, N. A. Al Kaabi, A. A. Alshehri, H. M. Ali, A. A. Rabaan, F. A. Aldubisi, C. Y. Yean, and N. Yusof, “Current and future technologies for the detection of antibiotic-resistant bacteria,” Diagnostics (Basel), vol. 13, no. 20, 2023.
C. N. D. Chinemerem, M. C. Ugwu, C. O. Anie, M. T. S. Al-Ouqaili, C. I. J. Chinedu, V. C. U. Victor, and M. Saki, “Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace,” Journal of Clinical Laboratory Analysis, vol. 36, no. 9, 2022.
M. H. A. Mdarhri, R. Benmessaoud, H. Yacoubi, L. Seffar, H. G. Assimi, M. Hamam, R. Boussettine, N. Filali-Ansari, F. A. Lahlou, I. Diawara, M. M. Ennaji, and M. Kettani-Halabi, “Alternatives therapeutic approaches to conventional antibiotics: Advantages, limitations and potential application in medicine,” Antibiotics (Basel), vol. 11, no. 12, 2022.
T. M. Uddin, A. J. Chakraborty, A. Khusro, B. M. R. M. Zidan, S. Mitra, T. B. Emran, K. Dhama, M. K. Hossain Ripon, M. Gajdács, M. U. K. Sahibzada, M. J. Hossain, and N. Koirala, “Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects,” Journal of Infection and Public Health, vol. 14, no. 12, pp. 1750–1766, 2021.